Breast Is Best: Benefits of Breast Milk for Infants Include Customized Antibodies

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The more we learn about breast milk and breastfeeding, the more the maxim “breast is best” rings true. Breast milk delivers crucial nutrients and antibodies to babies, helping to both protect them against infection and build their immune systems. New findings show each mother’s milk has unique immunity-boosting properties.

New research from the University of Pittsburgh School of Medicine shows that a nursing mother’s breast milk contains a unique composition of antibodies. Posted on July 18 in The Journal of Experimental Medicine, the study found that a nursing mother’s breast milk “profile” remains consistent in this aspect as long as she is nursing her baby (although it changes to adjust to her baby’s changing needs in other ways). This antibody “profile” remains consistent even through subsequent pregnancies.
It has been known for a while that breastfed babies have a different gut biome than formula-fed babies, with a higher proportion of beneficial bacteria. These researchers looked specifically at breast milk-derived maternal immunoglobulin (BrmIgA), an element of breast milk that helps to develop and strengthen the baby’s intestinal microbiota, and analyzed the reactivity of BrmIgA against bacteria found in infant microbiota.
“While each milk donor in our study had very different antibody profiles from one another, we found that antibodies from the same donor were quite similar over time—even across the span of months,” said senior author Timothy Hand, associate professor of pediatrics and immunology at the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh, in a press release.

Protecting against NEC

A baby’s early immunity is directed by antibodies from breast milk. The new research provides insight into why protection against different infections varies among infants and why some develop a life-threatening gut disease called necrotizing enterocolitis (NEC), the University of Pittsburgh reported.

“This means that if a baby’s [mother] happens to lack particular antibodies—such as those that fend off NEC–[the baby is] never going to receive that immunity. This could help explain why some babies get NEC and others don’t,” said Mr. Hand.

“In the future, better understanding of specific bacteria that are most dangerous for preterm infants at risk of NEC could help researchers develop antibodies that could be added to formula or breast milk to boost immunity,” they wrote.

Premature babies who are fed donor milk, which is commonly pasteurized, are more likely to develop NEC. The researchers attributed this to the pasteurization process that all human milk banks use on donated milk.

Any method of reducing contamination will affect the quality of donated milk to some degree, according to the breastfeeding support group La Leche League. But the group believes the method used by milk banks (called low temperature long time pasteurization, or holder pasteurization) is effective in eliminating pathogens while affecting quality as little as possible.

Ann Miller, a registered nurse and a certified lactation counselor at Cleveland Clinic Fairview Hospital in Fairview Park, Ohio, affirmed that pasteurizing breast milk results in loss of nutrients, but also still advocates for its use. “They don’t know exactly what the [extent of] the loss is, but we still feel that donor milk is better [than formula],” she told The Epoch Times.

“Breast milk from the mom to the baby is the perfect food. It’s tailored to the baby’s immune system,” she said. She told The Epoch Times that her facility encourages new mothers to initiate breastfeeding soon after they give birth—even if their child is in the neonatal intensive care unit (NICU) and cannot yet feed by mouth—to help build their babies’ immune systems.

Ms. Miller said:
“We encourage the moms [who have babies in the NICU] within six hours after delivery to begin pumping to stimulate their breasts to encourage their milk supply to come in. It is the colostrum, then the mature milk, that can really help to coat the digestive system and prevent NEC. You can’t find these antibodies [that are found in breastmilk] in formula. Mother’s milk, starting with colostrum, is best.”

Stimulating and Optimizing Milk Supply

Lactation is triggered by hormones, Ms. Miller explained, and once the placenta leaves the body after childbirth, she said, “it’s as if the body says, ‘OK, I need to pull in the prolactin and the oxytocin to make milk.’” Breast stimulation, along with skin-to-skin contact between mother and baby, makes this happen.
Breast milk composition changes in response to a baby’s needs as he or she grows. Early breast milk is high in protein, while over the first few weeks of a baby’s life, fat and carbohydrate levels in the mother’s milk increase.

Mothers can boost their nutrition to help them stay healthy and strong during this physically demanding time. “If a mother is healthy … then she has a better chance for a healthier milk supply,” said Ms. Miller.

Most importantly, she said, nursing mothers should focus on maintaining a healthy weight, eating a well-rounded, healthy diet, and avoiding both prescription and over-the-counter drugs if possible.

The American Pregnancy Association recommends breastfeeding mothers increase their caloric intake by about 250 to 500 calories each day, drink additional fluids, and eat protein-rich foods (lean meat, eggs, dairy, beans, lentils, and seafood low in mercury) plus whole grains, fruits, and vegetables.

Finding Donor Milk for Your Baby

Historically, mothers who were unable to breastfeed their newborns turned to “wet nurses,” who were usually family members or friends currently breastfeeding their own children, to nourish their babies.

Today, women in this situation may turn to milk banks if they wish to feed their babies donor human milk rather than formula. Milk donated to these banks is pasteurized and donors are screened for disease.

The Human Milk Banking Association of North America (HMBANA) website features a milk bank locator for new mothers in the United States and Canada who cannot breastfeed or who wish to donate their breast milk. HMBANA reports that in 2022, when the United States faced a baby formula shortage, it dispensed nearly 10 million ounces of donor milk to hungry babies.
La Leche League International also offers information about finding donor milk or becoming a donor.
Susan C. Olmstead
Author
Susan C. Olmstead writes about health and medicine, food, social issues, and culture. Her work has appeared in The Epoch Times, Children's Health Defense's The Defender, Salvo Magazine, and many other publications.
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