A decade ago, a small and unassuming brain sample arrived at Dr. Jeff Lichtman’s lab at Harvard University. Measuring less than a grain of rice, the 1 cubic millimeter of tissue contained 57,000 cells and 150 million synapses, each one a vital part of the brain’s intricate communication network.
Now, after a decade of collaboration with Google scientists, a monumental dataset—with 1,400 terabytes—has turned into the most detailed map of the human brain ever created.
The detailed 3-D reconstruction reveals beautiful structures in the brain. Neurons forming dozens of connections, mirror-image neural pairs, and networks far more complex than expected, are just some of the groundbreaking discoveries.
The map, now part of an open-access dataset online, opens the door to new understandings of human cognition, psychiatric disorders, and the architecture of our minds.
“There is the saying that ‘A map of synaptic connections is necessary but insufficient to understand the brain.’ In its current form it is still missing a lot of important information, but it is a step in the right direction,” Daniel Berger, a scientist in the Lichtman lab, told The Epoch Times.
All images below are by Google Research and Lichtman Lab (Harvard University). Renderings by D. Berger (Harvard University)
Excitatory neurons, color-coded by size, with red being the largest and blue the smallest. Cell cores range from 15 to 30 micrometers.
A single white neuron receives signals from more than 5,000 blue axons, with green synapses marking the points where the signals transfer.
Spatial video of a neuron.
Neurons with long dendrites and dendrite spine. In very rare cases, a single axon (blue) made repeated synaptic connections (yellow) with a target neuron (green).
One unexpected discovery in the study was the presence of “axon whorls”—tangled loops of blue axons—which typically transmit signals away from nerve cells. These structures were rare in the sample and sometimes appeared to be resting on yellow cells. Their purpose remains unclear.
A bundle of neurons relative to the size of a human hair.
Symmetric neurons, 360 degree view.
A single neuron (white) receives input from axons. Green axons transmit signals encouraging it to fire, while blue ones send signals to inhibit firing.
