A new study from the North Carolina State University has revealed a link between a widely used sweetener and a chemical compound known to cause DNA damage. The study found the chemical is formed when digesting the sweetener and trace amounts of the chemical are also found in the sweetener itself.
Sucralose is widely distributed under the trade name ‘Splenda,’ and is also contained in many food products, such as protein bars, shakes, and energy drinks. One of the chemical compounds contained in sucralose is sucralose-6-acetate.
Exceeding Threshold
The European Food Safety Authority has determined the threshold of toxicological concern for all genotoxic substances to be 0.15 micrograms per person per day.“Our work suggests that the trace amounts of sucralose-6-acetate in a single, daily sucralose-sweetened drink exceed that threshold. And that’s not even accounting for the amount of sucralose-6-acetate produced as metabolites after people consume sucralose,” Schiffman said.
Gut Health Concerns
In vitro tests were also conducted, exposing human gut tissues to sucralose-6-acetate.“Other studies have found that sucralose can adversely affect gut health, so we wanted to see what might be happening there,” Schiffman said.
“When we exposed sucralose and sucralose-6-acetate to gut epithelial tissues—the tissue that lines your gut wall—we found that both chemicals cause ‘leaky gut.’ Basically, they make the wall of the gut more permeable. The chemicals damage the ’tight junctions,' or interfaces, where cells in the gut wall connect to each other,” she added.
A leaky gut means that things normally excreted by the body leak out of the gut and absorb into the bloodstream.
The team also examined the genetic activity of the gut cells when exposed to the presence of sucralose-6-acetate.
“We found that gut cells exposed to sucralose-6-acetate had increased activity in genes related to oxidative stress, inflammation and carcinogenicity,” she said.
According to Schiffman, this raises many concerns about the potential health effects associated with sucralose and its metabolites.
Used Worldwide
Sucralose is a chlorinated artificial sweetener used worldwide as a sugar substitute in thousands of food, beverages, and pharmaceutical products. Its sweet taste was discovered at Queen Elizabeth College in London as part of a program to chemically modify sucrose (table sugar) for possible industrial applications, according to usrtk.org.Previous Studies
Controversies around the sweetener are not new. A 2016 study on the carcinogenic effects of sucralose in mice concluded “a significant dose-related increased incidence of males bearing malignant tumors,” contradicting previous data that the sweetener is biologically inert, according to the authors of the study that was published in Taylor & Francis Online.WHO Concerns
Concerns are not confined to the use of sucralose alone. Other artificial sweeteners have also been subject to controversy based on adverse effects on health.The WHO says that using non-sugar-sweeteners does not help with weight control in the long term and recommends using natural sugar alternatives such as fruit or consuming unsweetened food and beverages.
“The recommendation is based on the findings of a systematic review of the available evidence, which suggests that the use of NSS does not confer any long-term benefit in reducing body fat in adults or children,” the WHO said.
“Results of the review also suggest that there may be potential undesirable effects from long-term use of NSS, such as an increased risk of type 2 diabetes, cardiovascular diseases, and mortality in adults.”