Statistics Canada says manufacturing sales fell 2.8 percent to $71.0 billion, led by a drop in petroleum and coal product sales as well as lower sales in the machinery and computer and electronic product subsectors.
The agency says sales fell in 12 of 21 subsectors it tracks.
The petroleum and coal products subsector fell 10.3 percent to $8.4 billion in October as it saw lower prices as well as a decline in volumes.
The machinery subsector dropped 6.6 percent to $4.4 billion, while computer and electronic products fell 15 percent to $1.4 billion.
Sales of aerospace products and parts rose 6.9 percent to $2.2 billion.
Statistics Canada says total sales in constant dollars fell 2.2 percent in October, indicating a lower volume of goods sold.