San Francisco-Based Biotech Company to Close, Liquidate Assets

Third Harmonic Bio, once worth $1 billion, has been developing a treatment for chronic spontaneous urticaria, or hives.
San Francisco-Based Biotech Company to Close, Liquidate Assets
A view of San Francisco on June 13, 2018. Justin Sullivan/Getty Images
Jill McLaughlin
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San Francisco-based biopharmaceutical company Third Harmonic Bio has decided to shut down operations and liquidate assets, the company announced April 14.

Third Harmonic Bio, which began operating in 2019, is a clinical-stage biotech operation focused on treating dermal, respiratory, and gastrointestinal inflammatory diseases. It was once worth about $1 billion.

Its San Francisco location has fewer than 60 employees, according to LinkedIn. In February, the company began a 50 percent workforce reduction, according to a press release.
The company notified the Securities and Exchange Commission of its plans in a filing Monday.

The board of directors on April 10 unanimously approved the plan to liquidate assets and distribute remaining cash to shareholders. The board intends to seek stockholder approval June 5, according to the notice.

The company’s assets and intellectual property include its THB335 program, which is designed to treat chronic spontaneous urticaria, or hives, and cell-driven inflammatory diseases of the skin, airway, and gastrointestinal tract.

The treatment, which has not yet been approved for commercialization, was also expected to treat severe asthma and more diseases in the future, according to the company.

“Our management team and board of directors together have completed an efficient review of our strategic alternatives for maximizing the value of our assets and have determined that returning cash to shareholders and selling our assets, including THB335, is the best path forward,” said Chief Executive Officer Natalie Holles.

“We are proud of the work that our team has done over the past years to advance our science, to make tough decisions, and to act with integrity in the best interest of our patients and shareholders,” Holles added.

In another federal filing Monday, the company said it would be in a tough position if the dissolution did not go through.

“If our stockholders do not approve the Plan of Dissolution, we would have to continue our business operations from a difficult position, in light of our announced intent to dissolve and liquidate,” the company wrote in the filing.

Third Harmonic Bio has stopped all work that isn’t related to its drug prospect for treating chronic spontaneous urticaria.

If the company’s stockholders approve the plan, the company intends to file a certificate of dissolution and delist its shares of common stock from the Nasdaq Global Select Market.

The company estimates the total distribution to shareholders will be $245.6 million to $259.8 million, or about $5.13 to $5.42 per share.

If dissolved, Third Harmonic Bio would be the San Francisco Bay Area’s second major biotech company loss this year.

In March, Cargo Therapeutics announced it was winding down operations for its “next-generation cell therapy cures” for cancer patients.
Jill McLaughlin
Jill McLaughlin
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Jill McLaughlin is an award-winning journalist covering politics, environment, and statewide issues. She has been a reporter and editor for newspapers in Oregon, Nevada, and New Mexico. Jill was born in Yosemite National Park and enjoys the majestic outdoors, traveling, golfing, and hiking.