The U.S. Drug Enforcement Administration (DEA) issued a warning Monday about a nationwide increase in fentanyl containing a tranquilizer that can lead to amputation and has caused a spike in fatal overdoses.
“Xylazine and fentanyl drug mixtures place users at a higher risk of suffering a fatal drug poisoning,” said the DEA in a “public safety alert.” “Because xylazine is not an opioid, naloxone (Narcan) does not reverse its effects. Still, experts always recommend administering naloxone if someone might be suffering a drug poisoning.”
“People who inject drug mixtures containing xylazine also can develop severe wounds, including necrosis—the rotting of human tissue—that may lead to amputation,” the DEA noted Monday.
Figures released by the U.S. Centers for Disease Control and Prevention said that from August 2021 to August 2022, about 107,735 Americans died from drug overdoses. Some 66 percent of those overdoses were attributed to opioids like fentanyl, said the DEA.
“The Sinaloa Cartel and Jalisco Cartel in Mexico, using chemicals largely sourced from China, are primarily responsible for the vast majority of the fentanyl that is being trafficked in communities across the United States,” the agency said.
The animal tranquilizer isn’t a controlled substance under the U.S. Controlled Substances Act and isn’t approved by the FDA for human use. Health officials say that it is a central nervous system depressant that can cause drowsiness, slow breathing, slower heart rate, and can bring an individual’s blood pressure down to very low levels.
Earlier this month, the FDA confirmed that it moved to restrict the illicit importation of the animal tranquilizer, while allowing veterinarians to continue to legitimately use it. It is often used in tandem with the dissociative anesthetic drug ketamine—also a drug that has been illegally used in clubs for decades—to sedate dogs, cats, horses, deer, and other animals.
“While xylazine is not an opioid, it is dangerous because it can depress breathing, blood pressure, heart rate, and body temperature to critical levels,” the agency added. “Additionally, people who inject drugs containing xylazine can develop severe skin wounds and patches of dead and rotting tissue that easily become infected and, if left untreated, may lead to amputation.”
“A kilogram of xylazine powder can be purchased online from Chinese suppliers with common prices ranging from $6-$20 U.S. dollars per kilogram,” the report said.