The increasing number of suicides and fatal overdoses of women health care workers has accompanied rises in sickness, disability, and women leaving the sector. The total social and economic costs of a workforce in despair are yet unknown. A shortfall of 10 million people in the health care workforce (of whom 80–90 percent is female) is projected by the World Health Organization (WHO) for 2030 and is of critical concern.
Alarming Warnings by Health Care Workers in Despair
Recent studies noticed death by suicide and the risk for fatal drug overdose among women in health care is much higher than in the general population (1–10). It is not only female physicians; the risk is even higher for nurses and other health care workers, especially for those with the lowest-paid jobs and heaviest mental and physical workload who have been most stretched to the limits (7). Worldwide over the past several years, thousands of health care workers have died by suicide or fatal overdose, leaving family, friends, and the workplace in shock and grief.Suicide and self-harm have substantial social and economic costs (12). One death by suicide was calculated in the UK to cost the economy an average of 1.46 million pounds (13). In 2022, more than 360 nurses attempted suicide, and 72 medical professionals took their own lives in 2020 in the UK as data from the Office of National Statistics indicate. Analysis of mortality data from the U.S. Centers for Disease Control and Prevention from 2007 to 2018 identified 2,374 suicides among nurses, 857 among doctors, and 156,141 in the general population. However, the number of deaths by suicide or fatal overdose is grossly underreported. The WHO reports that more than 50 percent of suicides happen under the age of 50 years (14). To address this avoidable burden, a better understanding of effective and non-effective strategies is paramount.
Even before the COVID-19 pandemic started, women in health care reported substantial workplace stressors (9–11, 15–16). The past four years have put additional strain on women’s health. This is especially true for those women working as front-liners and first responders in highly demanding stressful situations. Increased complexity of care, understaffing, long working hours, additional bureaucratic tasks, moral injury, diminished autonomy, lack of decision-making ability, and low-paid jobs take a toll on their health.
Moreover, women routinely face tougher challenges at work and at home such as institutionalized barriers to career advancement and additional pressure for domestic labor by frequently being a caregiver for children or parents (9). In all parts of the world, health care workers are at high risk of violence, with 8–38 percent suffering some sort of violence in their careers. In 2023 for the first time in history, 75,000 health care workers in the United States went on strike (17).
An Epidemic of Emotional Trauma and Distress
Health care workers are trying to hide their symptoms by pushing themselves to work despite extreme pain, fatigue, memory inconsistency, exhaustion, and grief about not being able to deliver the quality of care patients need. Being overstressed, and with long-term understaffing, health care workers hardly take time to eat a nutritious meal.Toxic Cocktails: A Danger for Women’s Health
Suicides among the health care workforce often take place at work. The most frequently used method of suicide is overdose or poisoning (1–8). New studies suggest that most overdoses are caused by psychiatric drugs and multiple medications in the person’s system. Co-administration of antidepressants and opioids deliberate or unplanned is common. Women are more likely to be prescribed and take medication such as antidepressants and birth control pills and seem to be more sensitive and experience more drug side effects than men. Pharmacokinetic interactions may increase the concentrations and severity of side effects of antidepressants (27–28).Studies demonstrate potential side effects of psychiatric drugs and opioids as insomnia, burnout, fatigue, anxiety, pain, and suicidal thoughts (21–25). The risk of opioid-involved overdose death was nearly twice as high for health care support workers such as nursing home workers and home health aides as it was for other health care workers (7).
The interaction and side effects of the use of multiple medicines and concentrations are mostly unknown. This is especially true for women as most drugs have been poorly studied in women. Some medicine might even have more disastrous side effects than any benefit as seems to be the case for psychotropic medicine (26). Moreover, interactions of psychotropic drugs with immunosuppressive capabilities and COVID-19 mRNA vaccines have been reported (17).
Medicalization as a Coping Strategy
During the pandemic, prescription of antidepressants and use of other over-the-counter medication such as acetaminophen (paracetamol) which is often advised to temper vaccine side effects, has grown substantially. Although harmless in low doses, acetaminophen has direct hepatotoxic effects when taken in overdose or a wrong combination and may cause acute liver failure. Accidental or unintentional overdose usually occurs in patients who have been fasting or are critically ill with a concurrent illness, alcoholism, or malnutrition or have preexisting chronic liver disease (34).Acetominophen (single or combination products) is one of the most used medications in the United States, with 25 billion tablets sold in 2016. It is expected that treatment of trauma ailments and increase in chronic illness will fuel an increase in market sales from $9.8 billion in 2022 to $15.2 billion in 2033. However, after a report showed 8,700 poisonings with high rates of hospitalization and liver injury in 2019–2020 with a sharp rise among females, the Australian medicine regulator is considering restrictions on who can buy paracetamol (35). In Sweden, the sale of acetaminophen in supermarkets was banned in 2015 after the country experienced an overdose hike. Increased use of over-the-counter and controlled drugs may fuel a rise in acute liver failure.
Drug Theft and Diversion
Job stress and occupational burnout have been associated with increased risk of opioid use disorder, which in turn can increase risk of overdose. Those who prescribe or administer medication have ready access to opioids and other controlled prescription drugs. Drug theft and diversion of controlled drugs in hospitals and nursing homes appear to have accelerated worldwide, putting health care workers and patients at risk (36–38). Taking prescription medicine at work, almost 100 health care workers have been fired in the Netherlands. Moreover, the problems with understaffing in the Dutch health care sector have introduced the use of falsified certificates, with people from illegal drug networks entering health care organizations pushing the system to more errors and deficits (39).A Return to Humanity in Health Care
The problem of the rise in sudden death of health care workers comes against the background of increasing long-term sick leaves, permanent disabilities, and hundreds of thousands of health care workers leaving the sector, choosing less stressful and better-paid jobs.This is an unprecedented sign by dedicated women that they are no longer willing to work in a toxic and overstressed environment with complex tasks for often severely ill patients, for which they are underpaid. The health care system is facing increased clinical error rates and liability exposures, and patient satisfaction and organizational reputation are being adversely affected. This may develop into a catastrophe when public health officials do not take responsibility for a highly needed change ensuring that the workforce has the tools and resources needed to turn the wheel.
Hard times may turn positive when CEOs and insurance companies start to embrace the idea that quality of care and reputation start with a healthy, fairly paid workforce, gender equity, and a working environment choosing humanity and good nutrition. A well-nourished and empowered health care workforce that is occupied to guide people to health and work will be a win for all.
References:
- Zimmerman C, Strohmaier S, Herkner H et al. Suicide rates among physicians compared with the general population in studies from 20 countries gender stratified systematic review and meta-analysis. BMJ2024;386ce0778964 http://dx.doi.org/101136/bmj-2023-078964
- Gerada C, Sichu A, Griffiths F. Doctors and suicide. Female doctors are still at higher risk than their non-medical peers. BMJ2024;386q1758. http:/dx.doi.org/10136/bmjq1758
- Waters A, Doctor suicide: “All I could see were tasks mounting appointments being booked and people knocking on my door.” BMJ2024;386q1879. http://dx.doi.org/10136/bmjq1879.
- Lee AK, Fries CR. Deaths by suicide among registered nurses: A rapid response call. J. Psychosoc. Nurs. Ment. Health Serv. 2021, August; 59(8):3-4. http:/doi:10.3928/02793695-20210625-01.
- Dobson R. Suicide rate of women doctors in US is twice that of other working women. BMJ. 2007. Nov 10; 335(7627): 961. Doi: 10.1136/bmj.39391.422650.4E.
- Irigoyen-Otinana M, Csatro-Herranz S, Romero-Agult S et al. Suicide among physicians: Major risk for women physicians. Res. 2022. 110: 114441. http://doi.org/10.1016/psychres.2022.114441.
- Olfson M, Cosgrove CM, Wal MM, Blanco C. Fatal drug overdose risks of healthcare workers in the United States: A population-based cohort study. Am.Intern.Med.2023 Aug 176(8):1081-1088. doi: 10.7326/M23-0902.
- Olfson M, Cosgrove CM, Wall MM, Blanco C et al. Suicide Rise of Healthcare workers in the US. JAMA. 2023; 330(12):1151-1166. Doi:10.1001/jama.2023.15787
- Fond G, Fernandez S, Lucas G et al. Depression in healthcare workers: results from the nationwide AMADEUS survey. Int. J.Nurs. Stud. 2022. Jul 23;135:104328: doi: 10.1016/j.ijnurstu.2022.104328
- World Health Organization. (2019). Delivered by women, led by men: a gender and equity analysis of the global health and social workforce. World Health Organization. https://iris.who.int/handle/10665/311322. License: CC BY-NC-SA 3.0 IGO
- Women in Global Health. Policy Report The great resignation: why women health workers are leaving. October 2023.
- Peterson C, Haileysus T, Stone DS. Economic cost of U.S. suicide and non fatal self harm. A. J.Prev. Med. 2024. Jul;67(1):129-133. Doi:10.1016/j.ameprev.2024.03.002.
- The economic cost of suicide in the UK, March 2024. https://media.samaritans.org/documents/The_economic_cost_of_suicide_in_the_UK_-_web.pdf
- World Health Organization. Suicide worldwide in 2019 global health estimates. Published online 2021 Accessed December 2024. https:/who.int/publications-detail-redirect/9789240026643.
- Kaye D. 75.000 Kaiser nurses, pharmacists and other workers have walked off the job. NPR October 23 2024. https://www.npr.org/2023/10/04/1203225614/kaiser-permanente-historic-strike-health-care-workers-nationwide
- Pappa S, Ntella V, Giannakas T et al. Prevalence of depression, anxiety and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis. Brain Behav. Immun 2020. May 8; 88.900-907. Doi: 10.1016/j.bbi.2020.05.026
- Peeters C. The Collapse of Womens Health and Income. Brownstone March 6 2023
- Peeters C The Great Resignation in a Collapsing Health System. Brownstone January 24 2023
- Villa NAE, Fiore GMP, Espiridion W. Examining the mental health impact: investigating the association between suicide and Long Covid. Transformative Medicine (T-Med): 2024; 3(2):51-55. Hipps//:doi.org/10.54299/tmed/cqub3227
- Gender Paradox of suicide differs between men, women and transgender/gender diverse individuals. https://cams-care.com/resources/educational-content/the-gender-paradox-of-suicide/
- Gustafsson M, Silva V, Valeiro C et al. Misuse, Abuse and Medication errors Adverse events associated with opioids-a systematic review. Pharmaceuticals 2024, 17, 1009. https://doi.org/10.390/ph17081009.
- Chevance A, Tomlinson A, Ravaud P, et al. Important adverse events to be evaluated in antidepressant trials and meta-analyses in depression: a large intentional preference study including patients and healthcare professionals. Evid Based Ment Health 2022, 25 e41-e48. http//: dx.doi.org/10.1136ebmental-2021-300418.
- Warafi J, Chrobak AA, Slezak D et al. Unprescribed and unnoticed: retrospective chart review of adverse events of interaction between antidepressants and over-the-counter drugs. Front Pharmacol. 2022. Aug 29:13.965432. doi: 10.3389/fphar.2022.965432.eCollection 2022.
- Martinez AM, Martin ABB, Linares JJG et al. Axiolytic and antidepressant use and burnout: Optimism mediator in Spanish Nurses. J. Clin. Med. 2021.10,5741. https://doi.org/10.3390/jcm10245741
- Hoopsick RA, las S, Sun R. Differential effects of healthcare worker burnout on psychotropic medications use and misuse by occupational level. Soc.Psychiatry Psychiatr Epidemiol: 2024 Apr 59(4):669-6709. Doi: 10.1007/s00127-023-02496-y.
- Gotzsche PC, Young AG, Grace J. Does long term use of psychiatric drugs cause more harm than good? BMJ, 2015. M1y 12; 350:h2435. Doi: 10.1136/bmj.h2435.
- Llama M. Big Pharma’s role in clinical trials. Drugwatch, April 24, 2015
- Llama M. How the FDA let women down. Drugwatch, September 24 201
- Liu KA, Dipietro-Wager NA. Women’s involvement in clinical trials: historical perspective and future implications. Pharm. Pract (Granad) 2016 Mar 15. 14(1): 708. Doi: 10.18549/Pharmpract.2016.01-708
- Kiselinski K, Hockertz S, Hisrch D et al. Wearing face masks as a potential source for inhalation and oral uptake of inanimate toxins- a scoping review. Ecotoxicol. Environm. Staf. 2024 . Ap615.2715-11585. Doi: 10.1016/jecoenv.2023.115858.
- Yin A, Wang N, Shea PJ et al. Sex and gender differences in adverse events following influenza Covid19 vaccination. Biology of sex differences 2024. 15, 50. https//: doi.org/10.1186/S13293-024-00624-z.
- Pollitis M, Rachiotis G, Moutchori V et al. The Global Burden of Absenteeism related to Covid 19 vaccine side effects among healthcare workers. A systematic review and Meta-analysis. Vaccine 2024 Oct19;(1210);1196.doi.10.3390/vaccines12101196.
- Reusch J, Magenthauser I. Gabriel A et al. Inability to work following Covid-19 vaccination-a relevant aspect for future booster vaccinations. Public Health 2023Sept202:186-195. Doi:10.1016/j.puhe.2023.07.008.
- Livertox: Clinical and research information on drug induced liver injury, [Internet] Bethesda MD: National Institute of diabetes and digestive an kidney diseases 2012-Acetominophen [updated 2016, Jan 28]
- Chidiac AS, Buckley NA, Noghrehchi F, Cairns R. Paracetamo doing errors in people aged 12 years and over: an analysis of over 14,000 cases reported to Australian Poisons Information Centre. Drug. Saf. 2024. Dec 47(12); 1293-1306, doi 10:1007/s40264-024-01472-y.
- Fan M, Tscheng D , Hamilton M et al. Diversion of controlled drugs in hospitals: a scoping review of contributors and safeguards. J. Hosp Med 2019.Jul:14(7):419-4129. Doi:10.12788/jhm.3228.
- Brouk T. Purdue nursing researchers analyze medication theft in long term care facilities. March 4 2023 Purdue.edu.
- Grissinger M. Partially filled vials and syringes in sharps containers are a key source of drug diversion. Medical errors. December 2018. Vol 43, no 12.
- Aartsen C. Drugshandelaren en plofkrakers op grot Schaal actief in de zorg. SKIPR 5 november 2024
- Verdel R, Zorgpersoneel pikt pillen. Zoveel nachtdiensten is niet vol te houden. NOS 12 december 2024. https://nos.nl/nieuwsuur/artikel/2548094-zorgpersoneel-pikt-pillen-zoveel-nachtdiensten-niet-vol-te-houden.