Dealing with pandemics and other health emergencies is an important aspect of public health. Interventions must be weighed against potential direct and indirect benefits, the probability that an intervention can be realized, and the direct and indirect costs that will be accrued.
Such costs and benefits must include social and mental impacts, assessed within an ethical framework that respects human rights. Human populations are diverse in terms of risk, whilst priorities are influenced by cultural, religious, and social factors, as well as competing priorities arising from other diseases. This requires careful policy development and an implementation approach that responds to public need and is consistent with the will of the community.
The University of Leeds, through an initiative backed by Brownstone Institute, recognizes the need for publicly available evidence to support a measured approach to pandemic preparedness that is independent and methodologically robust. The REPPARE project will contribute to this, using a team of experienced researchers to examine and collate evidence, and develop assessments of current and proposed policies weighed against this evidence base. REPPARE’s findings will be open-access and all data and sources of data will be publicly available through a dedicated portal at the University of Leeds.
The Current State of the Pandemic Preparedness Agenda
Pandemic preparedness, barely on the agenda a decade ago, now dominates global public health messaging and funding. Humanity is reminded, in white papers from the United Nations, the World Health Organization (WHO), and other organizations such as the G7 and G20, that rapid action and investment is essential to avert a probable existential threat to human and societal well-being. Using COVID-19 as an exemplar case, these documents often warn us of far worse to come.A Divergence in Public Health Thinking
The past two decades have witnessed the increasing divergence of two schools of thought within global public health. The COVID-19 pandemic and subsequent pandemic preparedness and response (PPR) agenda have brought these to a level of vitriol, dividing the public health community. Health is a basic human need, and fear of ill health is a powerful tool for changing human behavior. Ensuring the integrity of public health policy is therefore critical for a well-functioning society.One school, formerly prominent in the era of evidence-based medicine and ‘horizontal’ health approaches, emphasized the sovereignty of communities and individuals as a primary or essential arbiter of policy. The risks and benefits of any intervention must be systematically defined and presented to populations with best available evidence, who then make rational decisions on health priorities within their own context.
A second school of thought, increasingly expressed over the past two decades, holds that a pandemic and other health emergencies constitute urgent threats to human health requiring centrally coordinated or ‘vertical’ responses that require universal implementation and should thus override aspects of community self-determination.
Health emergencies, or the risks thereof, are held to be increasing in frequency and severity. Moreover, these risks threaten humanity collectively, requiring a collective response. As a result, uniform and mandated responses aimed to mitigate these threats override everyday health concerns, and public health adopts a role of establishing and even enforcing the response, rather than merely advising.
COVID-19 and the Rethink of Roles and Rights
In the aftermath of COVID-19, the basis for the shift in priority of global public health, that pandemics are of increasing risk and frequency, is widely repeated by institutions driving this change. This is said to be part of an unprecedented conflation of multiple threats, or a ‘poly-crisis,’ facing humanity, associated with a growing human population, changing climate, increasing travel, and changing interactions between humans and animals.The proposed responses, including the potential for mass vaccination and restriction on human movement and healthcare access, carry their own risks. During the COVID-19 response, employment of these measures underwrote a major transfer of wealth from low to higher-income people, loss of education with knock-on effects on future poverty, and a significant rise in both infectious and non-communicable diseases.
Whilst such impacts are used to justify an earlier response, they present major risks both to population and societal health. While some will hold that no threat justifies restrictions on human rights and democratic norms, nearly all will agree that such measures are not justified if the extent of the threat is overestimated, and the risk of collateral harms are demonstrated to outweigh that of the pathogen.
Clearly, any such fundamental changes in the approach to public health, tried for the first time during COVID-19, requires a strong evidence base. Currently, this evidence base is poorly articulated or absent from documents supporting the international pandemic instruments under development.
What We All Should Know
If the evidence underlying the pandemic agenda is flawed or absent, then humanity is facing a different form of risk. We risk the reversal of health and social gains made through an unprecedented period of prosperity and prioritization of human rights across the world, and a return to a more colonialist structure of elite led ‘traveling models.’ Public health as a profession will have returned to its historical blight of assisting in the degradation of societies, rather than their enhancement.Moreover, we risk diverting a large amount of scarce resources from known communicable and non-communicable health threats that have everyday impacts. It is crucial to public health and to humanity that the current pandemic agenda be evidence-based, proportionate, and tailored to the overall good.
We have a short time in which to bring transparency and evidentiary reflection to this field. Both public health science and commonsense demand this. Pandemics happen, as do a wide range of preventable and non-preventable threats to health. They have been part of human society through recorded history, and it is prudent to prepare for them in a way that is fit-for-purpose and proportional.
Project Overview
Post COVID-19, global health governance is rapidly being remodelled on a stated imperative to address a major and rapidly growing threat of health pandemics. Under this new approach, health prioritization is changing and new regulations are being introduced to protect humanity from this threat. These changes will have major economic, health, and societal consequences. It is therefore imperative that proposed changes are made based on solid and best available evidence, so that policies are rational and likely to deliver the best overall outcomes. Policy-makers, and the public, must have access to clear, objective information about pandemic risk, costs, and institutional arrangements to enable this to happen.Overall Project Objectives:
Primary Objectives:Scope of Work:
The REPPARE team will address four interlocking work-packages:• The degree to which pandemics are a growing threat?
• How does this compare with other health priorities in terms of health and economic burden?
• Are current cost estimates of the PPR agenda appropriate and how do they weigh current costs against competing priorities?.
• What are the opportunity costs of the proposed diversion of resources to PPR?.
• Who and what are the greatest influences on the PPR governance and finance architecture, and how are these governance structures designed and operating?
• How are stakeholders, including affected populations, represented in priority-setting, and who is left out?
• Does the current architecture appropriately respond to identified risks/costs?
REPPARE will examine and build the evidence base relevant to the pandemic agenda over two years, but continually make data and analysis available to the public. The aim is not to advocate for any current political or health position, but to provide a basis on which such debate can occur in a balanced and informed fashion.
Humanity needs clear, honest, and informed policies that reflect the aspirations of everyone, and recognizes the diversity and equality of all people. The REPPARE team at the University of Leeds, with the support of Brownstone Institute, aims to contribute positively to this process.