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Inexpensive Treatment Responsible for India’s Success?
Getting back to ivermectin, Trial Site News reported2 that “Ten months into its battle with the SARS-CoV-2 virus, India is on track to become an unexpected warrior in the fight against this global pandemic. Although the densely-populated nation has four times the population of the U.S., India has less than half the U.S. COVID deaths.”While India had a daily positive test rate of nearly 100,000 back in September 2020, by the end of December 2020, the infection rate had dropped by 75%. While this rapid decline is by and large being attributed to strict lockdowns, universal mask wearing and extensive contact tracing and testing, the availability and use of effective treatments likely plays a pivotal role.
In late March 2020, India added hydroxychloroquine to its national treatment guidelines, urging the drug be used “as early in the disease course as possible.” It was not recommended for those hospitalized with severe illness.
Then, in August 2020, India’s largest state, Uttar Pradesh, which has some 230 million residents, added ivermectin to its recommendations and distributed the drug for home care free of charge. The state of Bihar, which has 128 million residents, also started recommending ivermectin, and by the end of 2020, Bihar and Uttar Pradesh had the lowest and second-lowest COVID-19 fatality rates in all of India.
Uttar Pradesh, however, took it a step further than Bihar. They also used ivermectin as a prophylactic, first among health care workers and then among people who had come in contact with a person who tested positive.
This drug makes far more sense in India as the vast majority of the population indeed suffer with parasites as a result of largely contaminated municipal water supplies.
Frontline Doctors Call for Adoption of Ivermectin
In the U.S., the Frontline COVID-19 Critical Care Alliance (FLCCC) is now calling for widespread adoption of ivermectin, both as a prophylactic and for the treatment of all phases of COVID-19.3 4“The data shows the ability of the drug ivermectin to prevent COVID-19, to keep those with early symptoms from progressing to the hyper-inflammatory phase of the disease, and even to help critically ill patients recover.” ~ FLCCC AllianceDecember 8, 2020, FLCCC president Dr. Pierre Kory, former Chief of the Critical Care Service and Medical Director of the Trauma and Life Support Center at the University of Wisconsin, testified before the Senate Committee on Homeland Security and Governmental Affairs, where he reviewed the evidence supporting the use of the drug. (He resigned from the University of Wisconsin Medical Center shortly after giving this testimony, saying the medical center wanted to restrict his freedom of speech.5) As noted on the FLCCC website:6
“The data shows the ability of the drug iIvermectin to prevent COVID-19, to keep those with early symptoms from progressing to the hyper-inflammatory phase of the disease, and even to help critically ill patients recover.
“Numerous clinical studies — including peer-reviewed randomized controlled trials — showed large magnitude benefits of ivermectin in prophylaxis, early treatment and also in late-stage disease. Taken together … dozens of clinical trials that have now emerged from around the world are substantial enough to reliably assess clinical efficacy.
How Ivermectin Protects Against COVID-19
Like hydroxychloroquine, ivermectin is an antiparasitic drug with a well-documented safety profile and “proven, highly potent, antiviral and anti-inflammatory properties.”12 It’s been on the market since 1981 and is on the World Health Organization’s list of essential medicines. It’s also inexpensive, with a treatment course costing less than $2 in countries such as India and Bangladesh.13- Inhibits replication of many viruses, including SARS-CoV-2 and seasonal influenza viruses. In “COVID-19: Antiparasitic Offers Treatment Hope,” I review data showing a single dose of ivermectin killed 99.8% of SARS-CoV-2 in 48 hours
- Inhibits inflammation through several pathways
- Lowers viral load
- Protects against organ damage
- Prevents transmission of SARS-CoV-2 when taken before or after exposure; speeds recovery and lowers risk of hospitalization and death in COVID-19 patients
“If someone ... says they want to do an RCT with placebo, that’s problematic for me,” Kory told Medpage Today.17 “I could not have a patient admitted to my care and give placebo knowing what I know about ivermectin.”One week after Kory and Marik presented their data, the National Institutes of Health updated their stand18 on use of the drug with a statement that they would not recommend for or against it. The FLCCC quickly followed up with their own statement:19
“By no longer recommending against ivermectin use, doctors should feel more open in prescribing ivermectin as another therapeutic option for the treatment of COVID-19. This may clear its path towards FDA emergency use approval.”
WHO’s Ivermectin Review
While a 75% reduction in mortality is impressive enough (which is the average reduction based on 18 trials according to the FLCCC20), a WHO-sponsored review21 suggests ivermectin can reduce COVID-19 mortality by as much as 83%. As reported by Swiss Policy Research:22“This result is based on in-hospital trials, so it does not yet take into account early ambulatory and prophylactic treatment. The authors of the review intend to include three more trials, due to be published sometime in January, before providing a final conclusion.”In the video above, Dr. Andrew Hill of the Department of Pharmacology at the University of Liverpool, U.K., who is leading this review, discusses the preliminary findings. At the end, he too describes ivermectin as a potentially transformative treatment against COVID-19.
Ivermectin Best as Prophylaxis
While preliminary evidence seems to suggest ivermectin can be useful at all stages of SARS-CoV-2 infection, its real strength appears to be prophylactic. December 26, 2020, Dhaka Tribune23 reported the findings of an observational study24 from Bangladesh, which looked at ivermectin as a pre-exposure prophylaxis for COVID-19 among health care workers.Fifty-eight volunteers took 12 mg of ivermectin once per month for four months. Only four (6.96%) came down with mild COVID-19 symptoms during the May through August 2020 trial period. In comparison, 44 of 60 health care workers (73.3%) who had declined the medication were diagnosed with COVID-19.
Other Effective Treatment Options
It’s worth noting that while the FLCCC is encouraging the use of ivermectin as a prophylactic and early at-home treatment, they also have a more comprehensive early treatment protocol available, as well as an in-hospital protocol.Nebulized Peroxide
Nebulized peroxide is a home remedy I recommend everyone familiarize themselves with, as in many cases it can improve symptoms in mere hours.Nebulizing hydrogen peroxide into your sinuses, throat and lungs is a simple, straightforward way to augment your body’s natural expression of hydrogen peroxide to combat infections and can be used both prophylactically after known exposure to COVID-19 and as a treatment for mild, moderate and even severe illness.
Nebulized hydrogen peroxide is extremely safe, and all you need is a desktop nebulizer and food-grade hydrogen peroxide, which you’ll need to dilute with saline to 0.1% strength. I recommend buying these items beforehand so that you have everything you need and can begin treatment at home at the first signs of a respiratory infection. In the video above, I go over the basics of this treatment.