1. Inhibits Vascular Calcification
Aged garlic extract has been shown to reduce multiple cardiovascular risk factors such as high blood pressure. A 2004 study published in Preventive Medicine evaluated its ability to inhibit vascular calcification, which serves as a marker of plaque formation in coronary arteries.In the double-blind, small pilot study conducted for a year, aged garlic extract demonstrated the ability to inhibit the rate of coronary calcification in patients on statin therapy compared to placebo.
2. Increases Vascular Elasticity and Endothelial Function
A stressful lifestyle is a known risk factor for the presence and worsening of atherosclerosis. A study published in Nutrition (Burbank, Los Angeles County, California) probed the effect of aged garlic extract in tandem with coenzyme Q10 (CoQ10) on vascular elasticity (how much our blood vessels can expand and contract) in a group of firefighters.The combination was linked to significant benefits to vascular elasticity as well as endothelial function among the firefighters, who experience high stress at work. The combination emerged as a potential way to prevent atherosclerosis in such individuals.
3. Inhibits Nanoplaque Formation
In a 2004 study published in Wiener Medizinische Wochenschrift (1946), garlic successfully inhibited lipoprotein associated arteriosclerotic nanoplaque formation. The experiments showed that garlic extract strongly inhibited calcium ions binding to proteoheparan sulfate, resulting in the blunting of the formation of what is responsible for “nanoplaque” composition and ultimately for the arteriosclerotic plaque generation.4. Protects Against Aortic Stiffness
A cross-sectional observational study published in Circulation evaluated healthy adults taking standardized garlic powder for at least two years and a control group, then measured the elastic properties of their aorta.5. Reduces Atherosclerotic Progression
Aged garlic extract was combined with supplements to check the effects on inflammatory and oxidation biomarkers, vascular function, and the progression of atherosclerosis in a study published in Preventive Medicine.In the trial, 65 subjects with intermediate risk for the disease were treated with either a placebo or a capsule containing aged garlic extract plus vitamin B12, folic acid, vitamin B6, and l-arginine, given daily for a year. The garlic and supplement mix were associated with improved oxidative biomarkers and vascular health, and a reduced progression of atherosclerosis.