Cancer Has Remained High for Decades
According to the statistics of the American Cancer Society, although the incidence of cancer in the United States has been declining slowly since the beginning of the 21st century, if we look at it over an extended period of time, we will find that the incidence of cancer is actually increasing, not decreasing.
Cancer May Not Be a Genetic Disease
“Why are so many people dying from cancer?” Seyfried asked. “Because the theory is wrong. The theory that underlies cancer is incorrect.”- Some cancers do not have genetic and chromosomal mutations;
- Some carcinogens do not cause gene mutation;
- Cancer “mutations” also occurs in normal cells, but some do not develop further into cancerous cells;
- The result of studying cancer as a genetic disorder is the development of personalized treatment or precision medicine, but there are off-target effects for some customized cancer precision medicines.
- Ancient people from thousands of years ago rarely had cancer, nor did the indigenous people living in the natural environment.
Under regular circumstances, normal cells develop into normal cells with controlled growth (case 1 in the figure below), while cancer cells develop into cancerous cells with uncontrolled growth (case 2).
Genes are stored in the nucleus. When the nucleus of a cancer cell was implanted into a cytoplasm containing normal mitochondria, the cell developed into a normal cell anyway (case 3). According to the somatic mutation theory, a cell with a cancer cell nucleus should have developed into a cancer cell.
However, when the researchers implanted a normal nucleus into a cancerous cytoplasm with abnormal mitochondria, they found that it still developed into a cancer cell (case 4).

The Biggest Difference Between Normal Cells and Cancer Cells
The theory that cancer is a metabolic disorder was first proposed about 100 years ago by a well-known German scientist named Otto Warburg. Normal cells break down glucose through aerobic respiration, but Warburg observed that cancer cells are different. Cancer cells obtain energy through fermentation, even in an aerobic environment. Thus, Warburg proposed, aerobic respiratory insufficiency is the origin of cancer.The truth, Seyfried said, is that “They [cancer] cannot breathe … they can’t get energy through oxygen, they can only get energy from fermentation.” All cancers can survive without oxygen, but they “cannot live without sugar, glucose, and the amino acid glutamine.”
Cellular aerobic respiration mainly takes place in mitochondria. Mitochondria, which are responsible for respiration, are damaged and hollow in all major types of cancer. The cristae, the wrinkled and wavy structures in the mitochondrial structure, are cluttered and defective. The abnormality of mitochondrial structure will change the function of mitochondria, resulting in the inability of cells to obtain energy through oxidative metabolism. This changes the cell’s metabolism from relying primarily on oxidation to fermentation.
Seyfried further explained that the various abnormalities in cancer cells are caused by the loss of normal function of cell mitochondria due to various reasons (including carcinogens, radiation, pollution, inflammation, age, viruses, etc). A large number of reactive oxygen species (ROS) will be produced when mitochondria are damaged, further attacking and destroying the nucleus.
“The mutations that we see in cancer come as the result of damage from reactive oxygen species,” Seyfried said. “The mutations are an effect, they are not the cause of cancer.”

Furthermore, Seyfried also talked about a phenomenon, that is, cancers with myriad variants share a consistent metastatic process. First, individual cells become cancerous and form tumors; the tumor cells then spread through the blood vessels and circulatory system to other parts of the body, forming new tumors.
Why do all cancers have the same metastatic process? How does this relate to the theory that cancer is a metabolic disorder?
Press-Pulse Therapy: Adjust Cancer Cell Metabolism to Improve Condition
Seyfried believes the existing cancer treatment system is “broken.” He said once people understand the metabolic theory of cancer, treatments like chemotherapy and radiotherapy will be replaced by new treatments.The purpose of a ketogenic diet combined with basic drugs is to control the ratio of glucose and ketone bodies in the blood to an ideal range while inhibiting the ability of cancer cells to acquire glutamine. In this way, we can “starve” cancer cells from a metabolic perspective, thereby achieving the same effect as cancer treatments.
An important aspect of “press-pulse therapy” is stress control and emotional management. Seyfried emphasized in the interview that people’s mental stress has a direct relationship with the development of cancer. When patients are diagnosed with cancer, they experience extreme panic and cannot rest or eat in peace. Excessive stress can raise blood sugar levels, which can feed cancer cells into rapid growth. As a result, cancer cannot be controlled. Easing the emotional and stress levels of the patient and his or her family can further stabilize the patient’s psychological and physical condition.
There have been many successful cases of cancer control by managing metabolism. Moreover, many patients use this method when traditional cancer treatments, such as chemotherapy and radiotherapy, are ineffective, or when cancer has spread.
Exercising, Fasting, and Avoiding High-Carb Diets May Keep Cancer Away
As for how an average person can maintain a healthy metabolism and prevent cancer, Seyfried said that by keeping the mitochondria in cells healthy, people are less likely to get cancer. He said this can be achieved through a certain period of fasting (drinking only water), a low-carb diet, and exercise.He also emphasized that high carbs and unnutritious foods such as junk food can cause cancer, and advised to stay away from such foods. It’s not just cancer, diseases like Alzheimer’s, Type 2 diabetes, and obesity, among others are all related to the Western diet.
“As soon as the Western diet comes into the population, you get cancer … and diabetes and things like this.” He also joked, “The bottom line is don’t eat anything and you'll get very healthy. Just drink water.”