A study by Yale University has found a Silent Allosteric Modulation (SAM) drug named BMS-984923to be capable of recovering neuronal synapse losses in mice models for Alzheimer’s disease (AD), creating hope for human dementia patients affected by AD.
Synapse [neuronal connection] loss “disrupt neural networks and cause cognitive decline seen in Alzheimer’s,” said Dr. Stephen Strittmatter, co-author of the study and founder of the company that holds the license to the drug.