What is Autoimmunity?
While the medical community at large does not recognize an exact root cause of autoimmune disease, the research is clear that many variables may contribute to autoimmune disease including genetic expression, internal and external environmental triggers, and hormonal changes. Seasons of stress and trauma have also been correlated with manifestations of autoimmune disease. All of these factors have the ability to disrupt the immune system and trigger autoimmune disease.To understand autoimmunity we need a foundational understanding of the immune system. The immune system is an intricate organization of various immune cells, organs, and biochemical messengers that work together to protect the body from foreign invaders. These foreign invaders include viruses, bacteria, parasites, environmental toxins, food, mold, and mycotoxins. When the body comes in contact with any of these threats, the immune system responds with an attack to overcome the threat. This is the body’s innate, natural defense mechanism often referred to as the inflammatory response.
In normal physiology, the body easily differentiates between your own cells and tissues and foreign invaders. Autoimmunity occurs when the immune system can no longer distinguish between the body and threats from the outside world. Basically, the body starts attacking its own tissue.
Viruses & Autoimmunity
The misfiring of the immune system can look different for each individual and oftentimes there are many factors that impact the immune response. We know that viral illness can trigger autoimmunity. Research shows a link between autoimmunity and viruses including Parvovirus B19, Epstein-Barr-virus (EBV), cytomegalovirus (CMV), herpes virus-6, HTLV-1, hepatitis A, hepatitis C, West Nile Virus, and rubella virus.These viruses have a strong correlation with the onset of autoimmune conditions like rheumatoid arthritis, systemic lupus, Sjogren’s syndrome, multiple sclerosis, Hashimoto’s autoimmune thyroiditis, and many others.
Several mechanisms within the immune system can trigger a misguided immune response due to a viral illness. These include epitope spreading, bystander activation, and cryptic signaling. Let’s take a deeper look into one of the most common—molecular mimicry.
In the process of molecular mimicry, the body initiates an autoimmune response because it sees similar amino acid sequences between foreign invaders and its own tissue. This case of mistaken identity leads the immune system to think specific tissues are the problem. The autoimmune condition that manifests is determined by what tissue(s) are being attacked.
COVID-19 and the Immune System
COVID-19 is the disease caused by the virus SARS-CoV-2. The immune system is the best defense against COVID-19. Once the body becomes aware of the viral invasion, it mounts an immune response that includes a cascade of chemical messengers and an inflammatory response within the body.The SARS-CoV-2 and the Autoimmune Connection
New research shows that various proteins within the body are cross reactive with monoclonal anti-SARS-CoV-2 antibodies and polyclonal anti-SARS-CoV-2 antibodies. That means these proteins are prone tof molecular mimicry and a SARS-CoV-2 infection has the potential to trigger chronic disease.When cross reactivity, or similar amino acid structures were studied between SARS-CoV-2 antibodies and various proteins within the body, it was discovered that SARS-CoV-2 antibodies initiated reactions in various tissues including barrier proteins (gut, brain, and lungs), gastrointestinal proteins, thyroid proteins, neural tissues, and more. This research shows that the extensive immune cross-reactivity between SARS-CoV-2 antibodies and different tissues within the body likely influence the severity of illness, initiate an autoimmune disease in certain individuals, and exacerbate autoimmunity in those with pre-existing autoimmune conditions.
Strategies for Supporting the Immune System Against Autoimmunity
Many dietary and lifestyle factors can go a long way in protecting you and your loved ones from viral infection and autoimmune disease. Making these changes can have a profound impact on the immune system.Nutrition
Eating a clean, nutrient-dense diet is foundational to a properly functioning immune system. Prioritize eating quality fats, proteins, and phytonutrient-rich vegetables and fruits. Consuming probiotic-rich lacto-fermented foods, bone broth, and collagen helps to maintain proper barrier function within the gut.Immune Support
Not only is eating an anti-inflammatory diet crucial for a strong immune system, supporting immune function through various supplements can also help to bolster it. While it is best to get some functional lab testing done to understand your body’s unique physiology, optimizing vitamin A, vitamin C, vitamin D, zinc, and glutathione status have been shown to support the body in the face of a COVID-19 illness and help prevent autoimmune disease. We cannot underestimate the importance that proper sleep, movement, diet, and stress have on the immune system.Support Barriers
As mentioned above, proper barrier function is crucial for safeguarding the body from developing autoimmune disease. Foundational to ensuring proper barrier integrity is supporting the microbiota. The microbiome, or the overall microbial balance of the body, impacts barrier function of the gut, lung, and brain. Eating an anti-inflammatory diet and supplementing with prebiotics and probiotics have been shown to protect barrier function as well as nourish the microbiome. If there is an underlying infection within the body, identifying and uprooting it will help restore barrier function.Avoid Toxins
Harmful toxins are ubiquitous in our environment today. Environmental toxins include pesticides and herbicides, heavy metals, chemicals, molds, and mycotoxins. On-going exposure to these toxins causes systemic inflammation. Environmental toxins have been shown to hurt the microbiome, and damage the gut, lung, and blood brain barriers. They also contribute to hormone imbalances, hinder phase one and phase two detoxification, and disrupt immune function.Manage Stress
We know that both acute and chronic stress can undermine immune function. Additionally, chronically elevated stress hormones wreak havoc on the gut, lung, and blood brain barriers. Emotional trauma and adverse childhood experiences (ACEs) are intimately intertwined with the overall stress load on the body. Working with a skilled clinician to work through trauma can have a profound impact on the way you see the world, overall stress, and immune function.We are just scratching the surface on how to prevent COVID-19, post viral syndrome, and autoimmunity. Future articles will provide more detail on how to work through a viral illness. In the meantime, if you are experiencing post viral syndrome or would like to put an autoimmune disease into remission, please see a functional medicine doctor who can help you work through your many options.
