The study found that 60 percent of the people showed a potent antibody response about 23 days after the onset of symptoms whereas only 16.7 percent had the same response 65 days later. The researchers found that people who recovered from severe infection had a stronger and longer-lasting antibody response.
“We demonstrate that the magnitude of the nAb response is dependent upon the disease severity, but this does not affect the kinetics of the nAb response. Declining nAb (neutralizing antibody) titres were observed during the follow-up period,” said the researchers in the preprint of the study.
The study consisted of 59 individuals and 6 health care workers with 77.2 percent of them being males. Sequential serum samples were collected from patients’ bodies one day to 94 days after the onset of symptoms between March and June.
The researchers said antibody responses to other coronaviruses have been found to wane over the course of time. In SARS-CoV2 and MERS, antibodies were found in some people 12-34 months after infection.
Many studies have worked on the neutralizing antibody response in the CCP virus or the SARS-CoV-2 infection but there’s a paucity of information on the longevity of the nAb response, according to the statement.
“This study has important implications when considering widespread serological testing, Ab protection against re-infection with SARS-CoV-2 and the durability of vaccine protection,” said the researchers.